Senior shortstop Gera Alvarez tied the score for the Raiders in the top of the second when he hit a solo home run over the left wall to extend his hitting-streak to 13 games.
Junior second baseman Joel Buchenauer gave Tech (20-12, 4-7) its first lead of the series when he blasted a line drive to right-center field, which scored Willie Durazo for a 2-1 lead.
The Huskers regained the lead in the bottom of the third on an RBI groundout by Jed Morris and an RBI single by Matt Hopper, which put Nebraska ahead 3-2.
Nebraska put up four singles in the bottom of the fourth and got key hits from Daniel Bruce and Drew Anderson giving the Huskers a 5-2 lead.
Matt Harbin replaced Tech starter Chris Phillips in the bottom of the sixth after he gave up a pair of two-out doubles.
Phillips suffered the loss for Texas Tech and falls to 3-2 on the season after giving up seven earned runs on 12 hits through 5 2/3 innings of work.
Jamie Rodriguez improved his record to 4-0 after holding Tech to just three runs on nine hits in eight innings.
Nebraska and Tech will complete the three-game series later today at 4:25 p.m.