Jody Roughton scored Jayce Tingler from third base on an RBI groundout putting the Tigers ahead 1-0.
Freshman right fielder Madison Edwards tied the game for Tech (23-13, 7-8) in the bottom of the second with an RBI triple to right field that plated Nick Blankenship, who led off the inning with a stand up double.
Missouri's Jayce Tingler put the Tigers ahead 2-1 in the top of the fifth when he drove in Luke Cassis with an RBI single to left field.
Missouri then added five more runs in the top of the ninth to seal the victory.
Junior Nathan Fouts (5-4) suffered the loss for Tech, despite throwing a season-high eight innings. He gave up four earned runs and six hits, while striking out five batters.
Garrett Broshuis (2-4) secured the win for Missouri after scattering seven hits over eight innings and allowing just one earned run.
Tech returns to action on Tuesday night vs. Howard Payne in a makeup game at 5 p.m. at Dan Law Field.