Kevin Durant added 17 points for the Longhorns (20-7, 10-3), who had all five starters score in double figures but didn't have a 20-point scorer for the first time this season.
It was the Longhorns' second rout of the Red Raiders at home in the last two seasons. Texas beat Tech by 34 in Austin last season.
This one left Tech coach Bob Knight sitting and stewing on the bench most of the game as the Longhorns built a big early lead and never let the Red Raiders threaten.
Texas is 17-2 against Tech in nine seasons under coach Rick Barnes, who is 12-2 against Knight, the winningest men's coach in college basketball.
Durant, who scored 30 or more points in six of his first nine Big 12 games, hasn't scored more than 21 in the last four.