And the group of participants expected to be on hand will include one of the top 10 players in the country in Chris Martin, a Bay Area native and commit to Notre Dame, as well as elite receiver Markeith Ambles.
Here is a look at who else will be at Kezar Stadium on Saturday.
Four years ago, Nathan Costa came from Hilmar to our first Bay Area Combine and a few years later, another Hilmar passer, Quinton McCown, will be on hand, hoping to repeat the same success Costa did in Berkeley that day.
Kent London from Milpitas will have a short drive, but the versatile athletic quarterback, who has a strong junior year, will get to show his ware.
Demetrius Williams from Sacramento (Calif.) Inderkum has an offer from Cal Poly as an athlete, but he'll spend a lot of time working with the quarterbacks as well as the defensive backs.
Kyle Miller from St. Francis in Mountain View has a short trip himself but he looked solid at the Badger/Scout 7on7 in Vegas and will be one of the featured throwers on Saturday.
A couple of Central California passers we're anxious to see are Kerr Taubler from Fresno (Calif.) Bullard and Lance Orender from Clovis (Calif.) Buchanan.
The running back corps will be strong in San Francisco, led by Mario Brown from Oakland (Calif.) Bishop O'Dowd, who ran the fastest forty last year in Oakland and was an all-combine pick.
One name to watch is local product Amir Carlisle, a sophomore who was one of 12 class of 2011 prospects named to the California Super Sophomore team by GoldenStatePreps.com. Also a gifted basketball player, Carlisle for Saturday anyway, will show it on the gridiron.
Malik Henderson from Stockdale is a guy we were impressed with on film and the Bakersfield native will get a chance to show where he stands during the spring.
Damon Treat from Vanden in Fairfield is a solid running back who may also spend some time on the defensive side of the ball on Saturday.
Derek Stewart is making his second straight visit to a Scout Combine, having been in Los Angeles a week ago, and the San Jose (Calif.) Piedmont Hills is coming off a fine showing there just like Anthony Herrera from Santa Clara (Calif.) Wilcox, who was solid last week.
Marquis Miller from Manteca is coming off a strong junior year, and is a smaller, but compact running back who runs big.
The receiver group is led by Markeith Ambles, the Georgia native who's doing a West Coast swing of schools, including to UCLA and Cal, and will be showing his stuff on Saturday in San Francisco. The four-star receiver is ranked #15 nationally by Scout.com and is one of the elite playmakers in the country.
Fairfield (Calif.) Vanden receiver Chris Broadnax is an intriguing prospect who's got good size and strength and could also play safety but he will work with the receivers on Saturday.
Poppy Livers is a smaller guy, but he's had a great spring and has shown tremendous gamebreaking abilities for St. Francis of Mountain View.
Andrew Berg was one of Los Gatos' main weapons during their CIF-CCS title season a year ago and he too was in Los Angeles last weekend and looks to keep his success rolling. Sam Joseph from Georgia is traveling out with Ambles but he's looking to make a name for himself.
Other receivers to watch include Najee Lovett from St. Mary's, K'Lan Anderson from Vallejo (Calif.) Bethel, Haran Piggee from Galt, Reggie Bell from Manteca (Calif.) and Eddie Gillies from Oakland (Calif.) Tech.
The tight end group isn't big but its effective. Sam Tomlitz from Archbishop Mitty in San Jose and Tim O'Hara from Bellarmine Prep in San Jose both came as underclassmen a year ago and are back.
And if he gets bored, Chris Martin may also run some routes with the tight ends.
The one-on-one's are back and figure to be pretty animated.
The primary offensive linemen to watch include Tevita Koniseti from Sacramento (Calif.) Burbank, Braden Lyons from Sonoma Valley (Calif.), Rick Davis from Fresno (Calif.) Bullard, Tyler Sanford from Los Gatos (Calif.) and Adam Sheffield from Branham HS as well as Matt Feagai from San Jose Piedmont Hills, who's brother Jacob was an all-combine selection two years ago.
This group begins and ends with Chris Martin, the top defensive end in the country. We first saw Martin last spring at our Oakland Scout.com Combine, where he worked with the tight ends and it was clear that day he was a star in the making.
With offers from all over the country, Martin committed to Notre Dame and he's the headliner this weekend. He's also going to do some reps with the linebackers.
Anthony Pohahau from Santa Clara (Calif.) Wilcox was a standout last week in Los Angeles and looks to do the same this week.
Alec Gletzer was on the all-camp team at the Las Vegas Badger/Scout 7on7 tournament and the Los Gatos (Calif.) backer is one of our headliners this year.
The top group of prospects is in the secondary, and Deone Buccanon from Fairfield (Calif.) Vanden is the big name. He's got several offers and will be the man on Saturday.
His teammate at Vanden, Davonne Yarbrough, also is getting major attention from the colleges and he'll also be in attendance.
Ken Egu, who's been a mainstay in the Concord (Calif.) De La Salle secondary will be in attendance as will Austin Fugate from Corcoran, Jordan Adams from Sacramento (Calif.) Inderkum (who's brother was all-combine a year ago) and Dominique Cole from Bellarmine Prep in San Jose.
The big named corners are led by Elijah Mitchell from Las Vegas, who impressed in his hometown during the Badger/Scout 7on7 Passing Tournament. Isaiah Lott from St. Francis in Mountain View is another WCAL prospect coming as is Jacob Barrow from Archbishop Mitty.
The name to watch though, is Tee Shepard, a freshman from Fresno (Calif.) Washington Union. Two years ago, Ebahn Feathers came from Washington Union and won the MVP honors at our San Francisco Scout.com Combine. Shepard, a prodigy of longtime defensive back guru Tony Perry, has the potential to be the best the valley has ever produced.
The action begins at 12:30 p.m. at Kezar Stadium in San Francisco, at the Southeastern part of Golden Gate Park