Four other players scored in double figures for the Huskies (2-0), who have won 118 of their last 120 games at Gampel Pavilion. UConn shot 71 percent and led 68-25 at halftime, tying a school record for points in a half.
Erica McKenzie had 16 points and Kendall Rodriguez scored 12 to lead Pacific (0-2), the last team to lose to Connecticut a year ago during the Huskies' record-setting 90-game win streak.
UConn lost at Stanford to break that streak and the Huskies host the No. 5 Cardinal in their next home game on Monday night.
Connecticut jumped to an 11-6 lead amid some sloppy play, committing three fouls and three turnovers in the first 5 minutes.
That prompted coach Geno Auriemma to sub in all three of his freshmen, a move that paid immediate dividends. They scored 13 straight points, including eight consecutive by Brianna Banks, during a 30-2 run that essentially put the game away.
"I thought [the freshmen] looked a little more comfortable than they did in the two exhibition games and [against Holy Cross] on Sunday," Auriemma said. "It is to be expected that with each game we play that they will get better. We are at the time right now where we're hoping to see some improvement."
That run also included the first two 3-pointers of Mosqueda-Lewis' college career. The sharp-shooting forward went 0 for 7 in her debut against Holy Cross. She hit her first four shots in this one, going 10 of 12 from the floor, including 5 of 6 from behind the arc.
"I think it was a matter of the shots going in. [Kaleena Mosqueda-Lewis] was 10-for-12. I don't know if she's going to shoot 10-for-12 every night. It was one of those days where things went her way, shots went in. [The assistant coaches] need to remind me to take her out because once I put her in; I'm reluctant to take her out."
The Huskies hit 10 of their 12 shots during the run and forced 10 turnovers. All 11 Huskies players got into the game and scored before intermission.
Banks had 12 points, Caroline Doty had 11 points and six assists, and Tiffany Hayes and Kelly Faris had 11 points apiece. Pacific turned the ball over 26 times, 17 in the first half, and UConn had 41 points off turnovers.
UConn's 68 first-half points tied the record set Jan. 6, 1998, in a 126-48 win over Providence. The Huskies took the foot off the gas pedal a bit in the second half, reaching 100 points with just over 6 minutes left to go up 100-46.
The game was the 999th in Pacific's history but just the team's 12th played in the Eastern time zone. This was the Tigers' first trip to the East Coast since 2009.
"I think you have to give credit to UConn," said Pacific coach Lynne Roberts. "I've never been in a game where either myself or the opponent shot 71 percent for the game. Maybe we didn't defend as well as we needed to, but some of that is that they shot the lights out as a team, and you've got to take your hat off to that and say good job. That's what you tell the team. At the end of the day a good team beat us, but a good team also shot exceptionally well."
UConn won last year's meeting 85-42 in Stockton, Calif., before falling at Stanford. The Huskies face the No. 5 Cardinal on Nov. 21 in Hartford with the home winning streak on the line. The last time the Huskies lost at home was in the 2007 Big East championship game to Rutgers. The NCAA counts UConn's postseason games played in Storrs and Hartford as home games.
The Tigers lost their season opener Sunday at Fairfield 56-47, shooting 28 percent from the floor. Pacific returns home to play the 1,000th game in program history on Sunday against St. Mary's.