Connecticut picked up where it left off, using dominating post play to build a 15-point lead. Northeastern closed within nine points on Jose Juan Barea's 3-pointer with 3:47 remaining, but UConn scored the next six points and led 43-28 at halftime.
Sophomore post Josh Boone led the Huskies with a career-high 19 points and 14 rebounds. Classmate Charlie Villanueva added 17 points and junior Denham Brown mixed jump shots with dunks as he put in 15 points. Freshman Antonio Kellogg had seven assists in 19 minutes of action.
Senior Marcus Barnes led Northeastern with 20 points, his last score early in the second half. UConn broke the game open shortly thereafter. Coach Jim Calhoun played everyone on UConn's roster, including French native Sami Ameziane, Husky fans apparent favorite walk-on this season.
UConn held Barea, who was averaging 25.0 points in the America East team's prior five games, to 10 points. The junior did hand out eight assists and pulled down five rebounds.
Northeastern (2-4), which had been hitting 42.2 percent of its shots, was held to 29.7% from the floor Monday. UConn outscored Northeastern 52-20 in the paint and finished with a 74-39 rebounding edge. Boone and Villanueva combined for six of UConn's 11 blocked shots.
Connecticut leads the series 32-4. Northeastern's last "W" was a 90-73 victory in 1985 when Calhoun was, in his pre-UConn days, the coach of the Boston-area team that included the late Reggie Lewis and current UConn assistant Andre LaFleur.
UConn continues playing New England teams when the Huskies travel to Amherst, Mass. for a 9:00 p.m. game with the Atlantic 10's Massachusetts Minutemen (2-2). One of Northeastern's wins was an 84-68 road victory over UMass.
Connecticut maintained its place in this week's polls, number 6 in USA Today / ESPN and number 7 in the AP ranking.
The Associated Press contributed to this report.