The Trojans (8-13, 3-5) are coming off two tough road losses in the desert, including an overtime thriller against Arizona State.
The Bruins (16-5, 6-2), also in the desert over the weekend, knocked off No. 6 Arizona before making the drive north and falling to Arizona State.
Wednesday's game will be the first time USC will play inside the renovated Pauley Pavilion. Tipoff is at 7 p.m.