USC (10-13, 1-9) entered Thursday night's game on a four-game losing streak after earning its first conference victory of the season Jan. 22 hosting California.
Utah (16-7, 5-6) came to the Galen Center looking for its first Pac-12 road win.
The Trojans fell to the Utes by 18 points, 84-66 when the teams met in Salt Lake City in January.
The Utes got the best of the Trojans in their second meeting, too, beating USC 79-70.
"Each game we lose it seems like there's a key stretch where we miss open shots," USC coach Andy Enfield said after the game. "We had less turnovers, more steals. But the key difference was a lot of loose balls and missing six layups in the first half. We need to convert and when another team goes on a run we need to make our shots, our open shots, and defend."
USC falls to 1-10 in the Pac-12 and remain in last place in the conference.
Enfield told Scout before the game that he wanted to change the starting lineup to reward players who were putting forth great effort and energy in practices.
"Our players have worked hard in practice and we win or lose as a team and I wanted to give everyone a chance tonight to play," Enfield said after the game.
Freshman guard Kahlil Dukes also saw rare action for the Trojans in Thursday night's game. He did not play in USC's last five contests. Dukes finished with ten points on 4-for-9 shooting from the field.
"We need production, we need a work ethic," Enfield explained. "We're a team. Our players give a great effort in practice and for the most part we are competitive in games. We've lost a lot of close ones but these guys aren't giving up and they're playing hard."
Senior guard JT Terrell did not play in the first half. He did not check in until four and a half minutes into the second half. Enfield said Terrell missed practices during the week due to illness and was not feeling well before tipoff.