The Crimson Tide drew first blood with a 3-pointer from Riley Norris but the Commodores responded with an eight-point run on a jump shot from Luke Kornet and two 3-pointers from Jeff Roberson.
Behind the inside shooting of 'Bama junior Shannon Hale, the Tide was able to narrow the lead to 14-15.
The 'Dores had a field day forcing things inside for layups and foul shots near the end of the first half. A flagrant foul on Wade Baldwin IV, followed by a layup on a fouled Kornet would help Vandy pull back away.
Hale led the Tide with 11 points in the first half, scoring two buckets in the final minute to narrow the lead to 33-31 going into the break.
Roberson nearly had a double-double in the first half with 10 points and eight rebounds.
After an ugly start in the first half where he shot 0-for-8 from the field, Damian Jones started the second off with a dunk to get things going for the 'Dores.
A 3-point shot from Riley LaChance would give Vandy their largest and first double-digit lead of the night but the Tide would go on a run to cut it back down to five points.
Vanderbilt would heat up again as an angry Jones made back-to-back dunks, one of which sent him to the line for a successful 3-point play.
The 'Dores would excel at the inside-out shooting, going to the line to shoot 21 free throws in the second half while shooting 5-for-7 from beyond the arc.
Roberson had a double-double with 16 points and 11 rebounds. LaChance led the team with 18 points and shot an impressive 5-for-6 from 3-point range. Jones ended the night with 13 second half points.
Vanderbilt will start a two-game road trip against rival Tennessee (9-8, 2-3) on Wednesday, January 20th in Knoxville, Tennessee.