The Longhorns took a one-point lead after Luke Kornet was called for an early foul.
Damian Jones would respond with a layup to give the 'Dores a small advantage before a dunk from Texas star Prince Ibeh.
Jones went 1-for-2 on the line to even the score for the only tie of the game.
The Longhorns went on an 11-0 run before another layup by Jones and a pair of free throws by Kornet would narrow the deficit to single digits.
Matthew Fisher-Davis and Jones would hit jumpers followed by a Joe Toye free throw to pull Vanderbilt within six, their closest for the remainder of the game.
Wade Baldwin IV only played ten minutes after suffering a quadricep injury during a collision from Texas's Ibeh who appeared to add some questionable force after the initial contact. The Commodores definitely missed their leading scoring and main ball handler deeper into the contest.
Texas went on a 13-4 run in the final seven minutes of the half to go into the locker room with a 31-16 lead.
The 'Dores would come out of the half firing on all cylinders as Jones would become a force inside and Fisher-Davis would start to heat up beyond the arc.
Sophomore guard Riley LaChance who had been quiet lately looked exceptionally better as he shot 3-for-4 from the field and added a 3-pointer on his only attempt of the half.
Fisher-Davis would catch fire in the second half, hitting 5-for-7 attempts from behind the arc while trying to bring the 'Dores back.
Kornet nailed a 3-pointer from the corner to bring Vanderbilt within seven but they would not come any closer as they could not stop the Texas offense.
Jones had another impressive game with a team-high 26 points and nine rebounds. Fisher-Davis was second on the team with 19 points and eight rebounds.
The 'Dores will return home to face theTexas A&M Aggies (18-3, 7-1) who as of Sunday are ranked 5th in the country. They will tip off at Memorial Gym on Thursday, February 4th at 6:00 PM.