The Commodores handled Missouri in Nashville with ease in an 86-71 victory.
Vanderbilt wasted no time to jump on top of the Tigers in the first few minutes after back-to-back 3-pointers by Jeff Roberson gave them a 15-2 advantage.
Missouri would narrow the lead but Vanderbilt shooting behind the arc was on point as Luke Kornet, Wade Baldwin IV and Nolan Cressler added treys to prop the 'Dores up by 15.
With less than five minutes remaining in the first half, a jumper by Kornet, followed by two 3-pointers by Matthew Fisher-Davis would extend the lead to 18.
Josh Henderson hit a jumper and the accompanying foul shot for a 3-point play and Baldwin IV made a layup in the final seconds to give Vanderbilt a 45-26 halftime lead.
After shooting over 41 percent from 3-point range in the opening half, the second was not as favorable to the 'Dores. The sole 3-pointer out of 12 attempts was made by Fisher-Davis in the opening 12 seconds of the final half.
Vanderbilt would lead by as many as 25 points after a jumper by Baldwin IV, who was fouled and made the free throw before the Tigers began to trim the lead.
The final 10 minutes turned into a dunkfest by Damian Jones and Luke Kornet who traded dunks inside. Jones would foul out after scoring 14 points and shooting 7-of-10 from the field.
Baldwin IV led the team with 17 points and seven assists while hitting 6-of-9 from the free throw line.
Five different Commodores scored in double figures, including Fisher-Davis and Roberson, while Kornet had a double-double with 13 points and 12 rebounds.
Vanderbilt will pivot to a crucial pair of road games starting with Auburn on Saturday, February 13th at 5:00 PM CT.