In a tribute to departing seniors, Coach Stallings gave the starting nod to Nathan Watkins, Carter Josephs and graduate student Josh Henderson, their first of the season.
It turned out that the 'Dores didn't need their normal starting lineup to sweep Tennessee for the first time since the 2009-10 season.
Watkins scored the first Vanderbilt basket and his first of the season in what was his second career start for Vanderbilt
The 'Dores did very well on the free throw line shooting 17-of-21 and took their first lead on a pair from Wade Baldwin IV. Shortly after, a 3-pointer by Baldwin gave the 'Dores a three-point lead.
The Vols would again take the lead before Jeff Roberson made a lay-up and the foul shot that gave Vandy a lead they would not hand over during a nine-point run.
After a trey from freshman Joe Toye, the 'Dores went on an eight-point run before the end of the half to put the Vanderbilt up by 19 points going into the locker room.
Memorial was thundering around the seven minute mark when three consecutive steals helped push Vanderbilt on a 15-0 run that gave them their largest 25-point lead of the night.
Nolan Cressler put in some very impressive time during his 12 minutes of play, scoring 11 points with two assists.
Baldwin IV led the team with 17 points, making all six foul shots, adding seven assists and six rebounds.
Damian Jones and Roberson each tallied 14 points. Jones shot 7-of-8 from the field with seven rebounds.
The Commodores will travel to College Station to try to sweep the 20th ranked Texas A&M Aggies on Saturday at 11:00 AM central time.