Damian Jones did not touch the scoreboard and played only seven minutes of the first half after picking up a second foul less than nine minutes into the game.
Luke Kornet and Joe Toye gave the 'Dores a first half lead with a pair of 3-pointers to start the evening.
The Shockers went on a run to take a 25-20 lead before Toye hit a pair of free throws. Shortly after, Toye was fouled on a successful layup before hitting another from the foul line.
The 'Dores led by five points with 1:37 remaining with an offensive rebound and jumper by Jeff Roberson.
Vanderbilt had 13 fouls in the first half which allowed Wichita to tie the game at the free throw line before heading into the locker room. Freshman Joe Toye's team-high 10 points were also very uncharacteristic for the 'Dores,
Things would seem to only get worse as the Shockers went on an 11-0 run on three 3-pointers to start things off the second half.
Riley LaChance would drop a trey and Jones finished off a three-point play with a foul shot to bring Vanderbilt within one with nine minutes remaining.
It would be pulled out of reach after Wichita State went on a 14-0 run in the waning minutes of the game.
The 'Dores final points of the 2015-16' season would come off a pair of Matthew Fisher-Davis free throws, his only scores of the contest.
Toye went scoreless in the second half, he and LaChance led the team with 10 points. Wade Baldwin IV was second on the team with nine points.
The Commodores will seek to improve in the off-season and see where their roster ends up after the NBA Draft.