Terrell's jumper just 10 minutes before halftime tied the score at 12.
Tack Minor's lay-up with 5 minutes remaining broke an 18-18 tie and ignited an 18-2 LSU run which would give the Tigers a seemingly insurmountable 36-20 halftime lead.
Vanderbilt caught on fire early in the second half. Steals by Vanderbilt's Corey Smith, Julian Terrell and Mario Moore helped ignite a 17-6 Vanderbilt run which cut the LSU lead to 5 at 42-37 with 16 minutes remaining in the game.
Mario Moore's 3-point shot brought the Commodores to to within one of the Tigers at 48-47 with 12:41 remaining. Moore, who made 6 of 11 three-point shots, finished with 30 points to lead Vanderbilt in scoring.
Darrel Mitchell's 3-point shot put the Tigers back up by 8 with 10:45 remaining. Vanderbilt would never pull to within less than seven points of LSU from that point on. Mitchell finished with 16 points for the Tigers.
LSU improves to 19-8 (12-4 SEC) with the win. The Tigers finish the regular season tied with Alabama for the SEC West lead. LSU will next face the winner of the Auburn-Vanderbilt game in the SEC tournament. Vanderbilt falls to 18-12 (8-8 SEC) with the loss. The Commodores can still earn an NCAA bid by winning two or more games in the SEC tournament.