"I challenged the guys a little more sternly than I usually do after Friday's loss and they responded," said Vanderbilt head coach Tim Corbin.
J.T. Wise staked the Tigers to a 1-0 lead in the first with a solo homer to left.
Back-to-back solo homers by Steven Waguespack and Jordan Mayer tied the game up at 3-3 in the fourth inning.
The Commodores loaded the bases with no outs in the fifth and scored two runs on Hernandez' single to right-center to get back the lead at 5-3.
"I wanted to make sure I came out as a senior and tried to give us the best opportunity to win," said Hernandez. "Luckily I was able to come up with some scoring situations and come through."
The Tigers plated a run in the sixth on a RBI double by Jarred Bogany off of reliever Tyler Rhoden. Will Harris followed with a single to right and Bogany attempted to score from second, but was thrown out at home by a strike throw from rightfielder Ryan Davis.
Ryan Flaherty got the run back in the seventh with a solo homer to right, his second of the season and first in SEC play.
Kurt Lipton got into the homer action in the eighth, with a solo shot to right-center for his first round-tripper in a VU uniform to make it 8-4.
Shea Robin had three hits to lead the Commodores offensively, while Brian Hernandez went 2-for-5 with three RBI to aid the cause. Ryan Flaherty chipped in with two hits and two RBI in the 11 hit attack.
Tyler Rhoden (3-0) picked up the win after giving up one run on two hits in 1.1 innings of work. He came on with two outs in the fifth in a 5-3 ballgame, with two men on and the SEC's leading home run hitter in Quinn Stewart at the plate. Rhoden struck out Stewart to end the threat and kept in tact the two-run lead.
Nick Christiani pitched the final three innings to pick up his third save of the year. He held the Tigers scoreless on one hit with a walk and three strikeouts.
LSU reliever Edgar Ramirez was charged with his first loss of the season to drop to 2-1. He allowed two runs on one hit in 1.1 innings of work with a walk and
The Commodores will close out the regular season next week with four games at Hawkins Field. VU will host Middle Tennessee on Tuesday at 6 p.m., before taking on South Carolina in a pivotal three-game series next weekend.
Vanderbilt 003 021 110-8 11 1 LSU 100 201 000-4 6 1
Davis, Rhoden (5), Christiani (7) and Hernandez. Forrer, Ramirez (3), Wilhite (5), Harris (8) and Liuzza. W- Rhoden 3-0, L- Ramirez 2-1. SV- Christiani (3). HR- VU: Flaherty (2), Lipton (1). LSU: Wise (11), Waguespack (2), Mayer (6).