VU finished as the sixth seed in the SEC and will take on the third seeded Georgia Bulldogs in the opening round of the conference tournament on Wednesday at 1 p.m. at the Hoover Met in Hoover, Ala.
"We wanted to be on a high going into the tournament rather than waltzing in," said Vanderbilt head coach Tim Corbin. "Once we get to Monday we will get back together again and get this thing going."
Honeycutt (5-0) limited the Commodores to six hits in eight innings and gave up three runs with six strikeouts and four walks.
For the third straight game, USC jumped out to a lead in the first inning, scoring two runs off of starter Ty Davis.
The Commodores cut the lead in half in the second on a RBI single by Ryan Davis.
The Gamecocks used a RBI single by Reese Havens and a sacrifice fly by Cheyne Hurst to take a 4-1 lead in the fourth.
Pedro Alvarez' two-run homer in the bottom of the fifth cut the lead to 4-3. It was his second of the weekend and 17th of the season, tying him for sixth on the school's single season list.
Phil Disher's solo homer in the eighth extended the USC lead to 5-3. Andrew Crisp's RBI double in the ninth made it 6-3.
Ty Davis (5-5) was charged with the loss after giving up four runs, three earned, on seven hits in 5.1 innings of work.
Alvarez led the Commodores with two hits and four RBI, while Brian Hernandez came through with two hits of his own. This weekend Hernandez put together a string of nine hits in nine official at-bats after recording base hits in his first two plate appearances of the day. Because he had a sacrifice fly during the streak, however, it doesn't go down as a consecutive hit streak per the official rule book.
South Carolina 200 200 011- 6(12)0 Vanderbilt 010 020 000- 362
Honeycutt, Cruse (9) and Kline. Davis, Shao (6), Christiani (8) and Hernandez. W- Honeycutt 5-0, L- Ty Davis 5-5. Sv- Cruse (2) . HR- USC: Disher (1). VU: Alvarez (17)