The US blew the game open with a four-run second inning, capped off by a three-run homer by Arencibia.
Josh Reddick's solo homer got the All Stars on the board in the bottom of the third.
Sean Doolittle (Virginia) hit the team's fourth homer of the night, a three-run shot in the top of the sixth to make it 14-1.
Ross Detwiler (Missouri State) picked up the win for USA, allowing one run on four hits in five innings with six strikeouts and two walks. Darwin Barney and Tim Federowicz (North Carolina) both made their pitching debuts for the team with an inning of scoreless relief each.
Several USA players had stellar offensive numbers on the night. Weeks went 4-for-5 with four runs scored, a homer and two RBI. Doolittle and Arencibia both had four RBI while Borbon added three hits to help lead the way.
USA 243 023 000- 14(16)2 GEORGIA ALL STARS 001 000 000- 171Detwiler, Barney (6), Federowicz (7), St. Clair (8), Moskos (9) and Clark, Federowicz. Nation, Fry (2), Goff (3), Carder (4), Courtwright (5), Crum (6), Lamb (7), Chambliss (8), Cash (9) and Gordon, Sutton. W- Detwiler 1-0, L- Nation 0-1. SV- . HR- US: Arencibia (2), Borbon (2), Weeks (3), Doolittle (2) GA: Reddick (1)