Senior Caroline Williams led the Commodores with 19 points. Senior Carla Thomas scored 18 points, tying her with former teammate Jenni Benningfield for 11th all-time in Vanderbilt history for scoring.
Sophomore Christina Wirth contributed 12 points, while senior Dee Davis dished out nine assists.
Ole Miss' Armintie Price led all scorers with 21 points. Price posted a double-double, with 11 rebounds. Five Rebels had three or more offensive rebounds in the game.
All five Ole Miss starters scored in double-figures, including 14 points from Alliesha Easley on 7-of-11 shooting.
Freshman Lauren Lueders scored the first six points for the Commodores on a pair of three-pointers, but was pulled from the game after picking up her second foul at the 15:34 mark.
Ole Miss led by as many as 14 points in the first half as the Rebels held the Commodores to 30% shooting from the field. The Commodores were outrebounded, 23-14, in the opening 20 minutes, while giving up 16 second-chance points to Ole Miss.
Vanderbilt opened the half on an 8-1 run to decrease the deficit to five points at 35-30. But the Rebels would expand the lead back to 12 with the help of six points from Jada Mincy.
The Commodores remain on the road this week, traveling to Columbia, S.C., to face the Gamecocks on Thursday, Jan. 11, at 6 p.m. CT.
Vanderbilt will play host to Florida on Sunday, Jan. 14, as the Commodores attempt to "Jam the Gym." An entire afternoon of family fun surrounds the SEC contest, which is schedule to tip-off at 2 p.m. Tickets are available for only $1 by calling 615.322.GOLD.