The 6-foot-3, 225-pound defensive end is the 27th commitment in the Hokies' 2017 class.
"I've decided to go to Virginia Tech," DeBose said. "It's a big relief for not only me, but my family. The recruiting process was good and I really enjoyed everything, but I'm excited about my future at Virginia Tech. It feels good that I've found myself a new home."
Although national signing day was Wednesday, DeBose waited to announce today because it is his mom's birthday.
"It feels great to be able to do this on her birthday," DeBose said. "She came to me last October and told me she wanted me to pick a school on her birthday.
"I saw the excitement and determination on her face. That's what she really wanted and I'm willing to go above and beyond for my family."
DeBose plans to compete for early playing time at Virginia Tech.
"They told me they have no defensive ends going into the spring and that they will have to borrow defensive tackles so they can have 11-on-11. So, having a chance to play as a freshman is very possible.
"They said they see me doing big things at Virginia Tech and they love my potential. They said I could play outside linebacker or defensive end. They also said I'm a need, not a want, and that meant a lot."
His relationship with the coaches played a significant role in his decision.
"I have the closest relationships with (tight ends) coach (James) Shibest and (defensive line) coach (Charley) Wiles," DeBose said. "They're just cool and it's easy to talk to them. They both also have great senses of humor and I really enjoyed the recruiting process with him."
The North Rowan standout is excited about playing for head coach Justin Fuente.
"Coach Fuente is a great coach," DeBose said. "I had a chance to sit down and talk with him and he was the most honest coach I've met. He's laid back, but he's about business and winning. He told me he's got big plans for Virginia Tech.
"I can just see myself playing for him. What he did at Memphis was amazing and winning 10 games in his first year at Virginia Tech was impressive, too. It just shows how good of a coach he is and I'm thankful to have a chance to play for him."
DeBose finished his senior with 85 tackles, including 27 for loss and 20 sacks.