If Wake Forest advances to the second round, the Deacons would play the winner of the West Virginia-Creighton game on Saturday at about 8:00 p.m.
All tickets for the Cleveland site are sold out.
The winner of that game will face either seventh-seeded West Virginia or 10th-seeded Creighton on Saturday.
Ten of Wake Forest's regular season opponents made the NCAA Tournament, including six non-conference foes. The complete list includes Arizona, Cincinnati, Duke, Illinois, Georgia Tech, George Washington, New Mexico, North Carolina, NC State and Texas. The Deacons went 10-4 in those games.
Wake Forest is making its 20th appearance in the NCAA Tournament. Last season, the Deacons reached the Sweet 16.