Outfielder Ryan Johnson and third baseban Jamie D'Antona both homeruns for the Deacons to lead the WFU offensive attack.
Meanwhile, reliever Brian Bach picked up the win for the Deacs, giving him a 1-0 record on the season.
The Deacs, #11 nationally, moved up to 16-2 overall with the win while #5 Georgia Tech fell to 14-3 overall, 0-2 in conference play.
Sunday's game against Georgia Tech was rained out.
Wake will hit the turf again Tuesday afternoon when the Deacs host Georgia at 3:00 at Hooks Stadium.