The Cougars (8-13, 1-4 Pac-12) recorded just five hits and Stanford (11-6, 1-1 Pac-12) used a two-run third inning and a four-run sixth to take any drama out of the game.
Cardinal starter Tristan Beck struck out 10 Cougars, allowed one earned on five hits over eight innings.
Cougar starter Ian Hamilton struck out nine but also allowed six runs in 7.1 innings of work.
Trek Stemp extended his hitting streak to nine games. Stemp has recorded a hit in all 20 of his starts this season.
Normally a three-game series would conclude on Sunday but with Easter Sunday on tap, the Cougs and Cardinal started the series on Thursday and will conclude the three-game tilt Saturday with first pitch slated for 1 p.m.