Sophomore fullback Jared Byers limped out of the first half with a sprained knee.
Junior wide receiver Jared Karstetter took a hard hit and suffered a concussion and rib damage.
Sophomore wide receiver Gino Simone's ongoing hamstring issues made a showing in Stillwater.
And senior linebacker Myron Beck, one of the Cougars' stars in fall camp, limped in and out of the second half.
THE INJURIES WERE a major blow to coach Paul Wulff, who had suffered two years of significant maladies during fall camp and was excited to be relatively unscathed headed into the season opener.
Most concerning, sideline reporter Bud Namek said at halftime, was that Galvin is expected to miss the remainder of the year.
The 5-foot-8 freshman from Berkeley, Calif., was expected to be a change-of-pace back to veterans James Montgomery, Logwone Mitz and Chantz Staden.
"We've known all along that he's very dynamic," Wulff said of Galvin, who is eligible for a medical redshirt. "We thought he would do special things for us this year."
OKLAHOMA STATE, on the other hand, barely batted an eyelash at its own injures.
Senior defensive tackles Shane Jarka (knee) and Chris Donaldson (ankle) were both hurt during a three-play span in the second quarter.
"It looks like we've lost a couple of guys for a game or two," coach Mike Gundy said at halftime. He shrugged and added, "We're going to play the freshmen."
Buoyed by senior running back Kendall Hunter, the Big 12's leading rusher in 2008 who racked up 208 yards rushing in the first half alone, his team was leading 38-10.
It's not like he had much to lose.
Radio color commentator and former WSU coach Jim Walden wasn't as thrilled about the Cougars' reliance on freshmen, though.
"I think we've got too many doggone young kids out there," he said of the defense, which only started four seniors.
Wulff agreed, but was a little more specific.
"We played like a team that's not very mature at times," he said. "We were inconsistent throwing the football.
"We've got to get better. We need those guys to continue to grow."
WULFF ADDED THAT his team's opening drive didn't inspire much confidence. Sophomore quarterback Jeff Tuel handed the ball off to Montgomery, a senior, but failed to make the connection. Oklahoma State defensive end Ugo Chinasa pounced on the ball and the Cowboys were in business at the WSU 15-yard line.
It took just two carries by Hunter to put the Cowboys on the board -- and the Cougars in a hole out of which they never climbed.
"They almost played like they didn't want to make mistakes," Wulff said of his team.
Then again, some of the players almost didn't play at all.
Walden said the team bus carrying the quarterbacks and wide receivers never made it to Boone Pickens Stadium. The Cougars had to leave the broken-down vehicle on the side of the road and bring the players aboard another bus to get to the game on time.
"I think this football team is going to grow a lot," Wulff said. "We're a lot better than the score."
"It felt pretty good," Wilson said. "Once I got the hang of everything … it was easy."