Tim McCabe had three hits and an RBI, Stan Psluszny blasted another home run, and Jard Rine, Lee Fritz and Grant Psomas each had two hits.
WVU's Jason DiAngelo pitched a gutty game, allowing five runs (four earned) and striking out seven, including the final Irish batter of the game with the tying run on first.
In the opener, Notre Dame's Chris Niesel outdeuled West Virginia's Shawn Miller for a 1-0 win. Miller pitched an excellent game in the seven inning contest, allowing only four hits and one run, which was unearned.
Notre Dame scored the game's only run in the bottom of the sixth when Matt Macri scored on a Mountaineer error with two outs.
Niesel allowed only one WVU hit, a single by Lee Fritz.
The third and deciding game of the series will be played on Sunday afternoon.
The day's Big East action resulted in a tightening of the standings, as Rutgers split two games against UConn and Virginia Tech swept a doubleheader. The Irish retained their half game lead over the Scarlet Knights, and kept WVU one game behind them. The Hokies trail the Mountaineers by two games.