Bulger and Cole got the Mountaineers off to a hot start as they combined on ten of the first fifteen points to give WVU a 15-5 lead.
That was just a warmup, however, as the tandem continued to pour in the points. They combined for the next nine points for the Mountaineers as the scored moved to 24-11.
The lead was pushed out to 19 as Owens connected on back-to-back three-pointers, and Davis-White hit a three of her own to push the score to 33-14.
The first half was all WVU, as the Mountaineers ran out to a 49-24 lead. West Virginia shot an astounding 71 percent from the field and 55 percent from three-point range in the opening 20 minutes.
The Cardinals cut the lead to twenty in the second half on a jumper by Patrika Barlow, but that was as close as the Cardinals would get. WVU scored 50 second-half points and ended up shooting 62.3 percent (33-53) overall.
WVU was out-rebounded by the Cadinals 37-32, but won the turnover battle as WVU had 15 turnovers to Louisville's 21.The big stat of the game was 26 points from West Virginia's bench.
Ashley Powell contributed a career-high 10 assists; for the game WVU dished out 19. The win takes WVU's record to 9-4 overall, and 2-1 in Big East play. Louisville falls to 12-3 overall and 2-1 in the Big East -- their first ever loss in conference play.
Coach Mike Carey's squad will next be in action on Saturday as part of a double header at the Coliseum. The men will have the early game at 2:00 p.m., when they face Marquette, while the women will play at 4:30 p.m. against the Georgetown Hoyas.