Northwest, which ended the season with a five-game losing streak, finished 1-6 overall. It's the Rangers' worst record since 1970 when they were 2-8.
It looked as though Northwest would claim the lead with just over three minutes remaining in the contest. The Rangers had the ball third-and-goal at the Trojan one-yard line, but Mississippi Delta's defense stopped Northwest on two consecutive plays to take over downs.
The Rangers got the ball back with two minutes left in the contest and had a chance to tie the game, but Billy Bishop's 50-yard field goal went wide right and gave the Trojans the victory.
Northwest finished the contest with 390 yards of total offense compared to Mississippi Delta's 295. The Rangers rushed for 270 yards on 52 attempts, including a season-high 140 yards from freshman running back Bryan Fitzgerald.
The Trojans claimed a 7-0 lead in the first quarter when running back Damian Davis scored on a 36-yard run.
Northwest responded in the second period by recording the first its two safeties in the game. The Rangers took a 9-7 lead when Fitzgerald found the end zone on a 38-yard run.
The biggest play of the contest came with one second left before halftime when Mississippi Delta quarterback tossed a 79-yard touchdown pass to receiver Ryan Mason.
Northwest scored the only points of the second half on a safety with 6:49 remaining in the game.