Taking the first two of a three game set, the Cubs will go for their second series sweep of St. Louis, this season, on Sunday.
Losing their first series at Busch Stadium is the least of the Cardinals problems.
First baseman, Albert Pujols (oblique muscle) could miss up to six weeks due to an oblique injury he suffered on a play in the second inning of Saturday's game.
Pujols will be evaluated again Sunday, June 4, but is expected to be placed on the disabled list.
"Obviously, we have significant concerns about the severity," team physician Dr. George Paletta said. "This injury can put you out for weeks."
Paletta said Pujols, who pulled up and grabbed his right side while chasing a foul pop by Ramirez in the second, could be out for as long as six weeks.
"If you told me right now he'd be out two weeks, that's a lot better than the rest of the year," manager Tony La Russa said. "I just don't think after talking to Dr. Paletta that two weeks from now, Albert will be ready to go."
The Cardinals were already playing short, with Jim Edmonds who has missed five of the last six games with what was diagnosed on Wednesday as a mild to moderate abdominal wall strain and his status remains day-to-day. Scott Spiezio has missed all four games of this homestand with an upper respiratory tract infection and there is no timetable for his return.
Mark Mulder (5-4) lost his third straight start, allowing eight runs and 12 hits, five of the runs earned, in 6 2-3 innings.
Mulder had won his last two starts vs. the Cubs and going into Saturday's game, he was 2-2, with a 3.75 ERA career vs. Cubs. He won his last start vs. Cubs on 4/21/06 at STL, in a 9-3 win for St. Louis.
The Cardinals are now 8-4 in games started by Mulder in spite of his three straight losses.
Jason Marquis will make his 12th start tomorrow and his second this year against Chicago. He is currently on a four-game winning streak and will try to prevent Chicago from their second sweep of St. Louis this season.
The Cards were swept in a 3-game series at Wrigley Field during the first weekend (April 7-9) of the season.