Looper's home run allowance swelled to 22 after he surrendered three Tuesday, two of them on hanging breaking balls.
Once again, the Cardinals could do nothing against former teammate Jeff Suppan, who beat them for the third straight time.
Center fielder Jim Edmonds delivered the Cardinals' only run with a sacrifice fly. But Edmonds, who had missed more than a week of starts with strained groin muscles, left the game shortly after making a diving catch in the outfield.
"He felt a little something," said La Russa, who removed Edmonds in the sixth inning after the latter popped up on a half-swing.
BREWERS 9, CARDINALS 1: 1B Albert Pujols, starting for the second consecutive night though having to favor his sore legs, singled and doubled but could not score or drive in his 100th run of the season. The Cardinals managed to get by with two pitchers, but RHP Braden Looper allowed three homers and RHP Kip Wells offered up No. 50 to Milwaukee 1B Prince Fielder, who had two homers on the night.
NOTES AND QUOTES
--The road has been unkind to the Cardinals this season. Their 9-1 loss at Milwaukee on Tuesday night was their 11th defeat in a row away from home, and they are 30-46 on the road with five games remaining. The Cardinals hadn't lost 11 straight on the road since 1978.
--RHP Brad Thompson, who allowed just one run in six innings in a win on Saturday, will work on three days' rest Wednesday night.
--SS David Eckstein committed his 20th error of the season and third in three games.
--Manager Tony La Russa didn't seem pleased that RHP Jeff Suppan had come up and in, about head high, on 1B Albert Pujols as he walked Pujols in the sixth. "I don't have any comment," snapped La Russa. To all questions about the Brewers and Suppan, La Russa said, "Go talk to the Brewers."
--OF Rick Ankiel didn't start after fouling a ball off his leg on Monday. He did pinch hit in the sixth and grounded out with the bases loaded.
BY THE NUMBERS: 27 -- Number of games out of 58 in which closer Jason Isringhausen pitched in a non-save situation.