Corey Patterson homered, his first of the season, as part of the Cubs' scoring and Neifi Perez collected three hits while getting the start at second base. Jake Peavy went six innings for the win, allowing two runs on six hits with seven strikeouts.
In Game 2, Prior's 2005 debut was a smashing success. He tossed six shutout innings, striking out six and walking one along the way. The Cubs jumped out to a 7-0 lead in the early going. Derrek Lee hit a three-run bomb in the first inning off Padres starter Brian Lawrence, and the Cubs got four in the second thanks in part to a pair of RBI singles by Patterson and Jeromy Burnitz.
Lawrence's struggles continued, allowing seven runs on nine hits in 2.2 innings. He fell to 0-4 lifetime against the Cubs.
Patterson made it nine straight games with a hit to open the season. He is the first Cubs player to do so since Brian McRae in 1996. With his six K's, Wood moves to within two strikeouts of Bill Hutchinson for fourth on the Cubs' all-time list. Prior matched a career-best with only four hits allowed. The last time he allowed that few hits in a start was on April 9, 2003 at Wrigley against Montreal. Michael Barrett started Game 1 and finished 0-for-3; he is hitless in his last 11 at-bats. Derrek Lee collected three hits and is now 60 shy of 1,000 for his career.