Mitch Jones, who played at Las Vegas last season, drove a shot over the left-field wall in the ninth with Luis Maza on base to break up the shutout.
Matt Kemp singled twice, Brad Ausmas beat out an infield hit and Jones' blast were the only hits Los Angeles could manage. The Dodgers left three on base.
In the meantime, the host Mariners whacked out an even 20 hits off eight Dodgers pitchers. Only Erick Threets escaped without allowing a run.
Chad Billingsley started and after a shutout first inning, allowed a single run in the second and was tagged with the loss.
It was the opening game of the exhibition season for the Mariners and starter Eric Bedard proved that when he drilled a photographer behind the plate on his first warmup pitch of the game.
Catcher Brad Ausmus beat out an infield single with one out in the first inning but designated hitter Russ Martin bounced into a double play.
Chad Billingsley started and used only 13 pitches - eight strikes - and working around a looping opposite-field single before popping up old friend Adrian Beltré to end the inning.
A second double play, grounded into by Mark Loretta in the second inning after Matt Kemp had singled, kept the Dodgers off the board again.
Billingsley allowed a one-out double into the left field corner by Matt Tuiasosopo in the bottom of the second and Franklin Gutierrez singled him home for the first run of the game.
Shawn Estes started the third inning for Los Angeles, appearing in Dodger Blue after many years with names like "Giants" and "Padres" across his chest.
The new uniform (#36), didn't bring him much luck. A bad-bounce ground ball that cleared leaping Mark Loretta and an error by shortstop Tony Abreu on what looked like a double play ball set the stage for a two-run double to the left field wall by Beltré and a ringing double to the right-center field wall by Bryan LaHair quickly made it 4-0.
He finally ended the inning with a long fly to center that Kemp pulled down in front of the 403-foot sign.
His second inning was almost as nightmarish. A couple singles, an error by Loretta at third and a long triple to right field drove accounted for two more runs. Estes was out of his alloted pitches and left the game in favor of Tanyon Sturtze.
Beltré continued to punish his old team with an RBI single, his third RBI of the game, before Sturtze could put strike out two to put out the fire and after four, Seattle led 8-0.
Kemp collected the third Dodgers hit leading off the fifth inning, a ground ball into right field. Then, on an attempted steal of second, Loretta popped to second and Kemp was nailed trying to get back to first base.
In five full innings, the Dodgers had collected three singles and a walk but left only one of them on base due to three double plays.
Seattle added to the Dodgers woes and their total with a single and back-to-back home runs off Travis Chick in the sixth inning making it 11-0.
Greg Miller allowed three singles, a bases-clearing double and a walk, leaving after throwing 24 pitches, 11 of them strikes. Justin Orenduff took over with runners at first and second and worked around a walk that loaded the bases, striking out the side to end things.
But Orenduff fell under the same black cloud that hung over the rest of the squad, allowing a leadoff double and a walk in the last of the eighth. A single ended his day and (#92) took over and was also hammered, running the score to 18-0.
Mitch Jones slugged a shot over the left field wall in the top of the ninth with Luis Maza on base with a walk to break up the shutout.
The Los Angeles record falls to 1-2 in the young season and they travel to Tucson today (Saturday) with Clayton Kershaw, James McDonald and Scott Elbert, among others, scheduled to work the game.
Score by Innings Los Angeles 000 000 002- 2 Seattle 013 403 34x-18 Los Angeles ab r h bi ave Pierre lf 3 0 0 0 .000 Jones lf 1 1 1 2 .333 Ausmus c 1 0 1 0 .500 May c 2 0 0 0 .000 Martin dh 2 0 0 0 .500 DeJesus ph 2 0 0 0 .000 Loney 1b 2 0 0 0 .400 Pascucci 1b 1 0 0 0 .500 Kemp cf 2 0 2 0 1.000 Repko cf 2 0 0 0 .167 Loretta 3b 2 0 0 0 .200 Luna 3b 1 0 0 0 .000 Paul rf 2 0 0 0 .375 Hoffmann rf 0 0 0 0 .667 Abreu ss 1 0 0 0 .125 Castro ph-ss 2 0 0 0 .600 Hu 2b 1 0 0 0 .200 Maza 2b 1 0 0 0 .000 Totals 28 2 4 2 Seattle 46 18 20 17 Error-Loretta, Abreu, Luna. DP-Seattle 3. LOB-Los Angeles 3, Seattle 9. HR-Jones 1 (1). Los Angeles in h r-er bb so era Billingsley 2.0 3 1-1 0 0 4.50 Estes 1.1 6 7-5 0 0 33.75 Sturtze 0.2 1 0-0 0 2 0.00 Threets 1.0 0 0-0 0 2 0.00 Chick 1.0 2 3-3 1 0 27.00 Miller 0.1 4 3-3 1 1 81.00 Orenduff 0.2 2 3-3 2 2 40.50 Halsey 1.0 2 1-1 0 0 9.00 T-2:54. Att-4,849.