Pineiro (3-3) evened his record despite another frustrating outing. An Edgar Martinez single spotted Pineiro a 2-0 lead in the first inning, but the young right-hander couldn't keep it for long.
Struggling to find his release point, Pineiro gave up three runs to the Tribe on five base hits in the third inning.
Down 3-2, that's when the right-hander began to settle down, shutting the Indians down for the next four innings.
That gave the hot Mariners bats to take advantage of Cleveland youthful pitching staff.
Indians' starter Brian Anderson lasted only four innings. He allowed six earned runs on nine hits.
The big blow came on a two-run triple off the bat of Mariners' left fielder Randy Winn, scoring Mike Cameron and John Olerud. A single by Cirillo scored Winn, and a double by Ichiro plated Cirillo to make it 6-3.
Indians' reliever Jerrod Riggan, a native of Brewster, Wash., came in and allowed two more runs in two innings of relief to break the game wide open in Seattle's favor.
Anderson took the loss to drop to 2-4 on the season.
Times are a Changin': The Indians, once the toughest ticket in professional sports, drew only 16,721 fans on the blustery night at Jacobs Field.
Getting Shigge with it: Shigetoshi Hasegawa's scoreless ninth inning shaved his ERA down to an amazing 0.40 on the season. To date, he has allowed only one earned run in 22 and one-thirds innings of work.