Luther Hackman (1-0) worked the seventh for the win.
Forty-six year old Ex-Met Jesse Orosco came on in the bottom of the ninth with two outs and the tying run on third to strike out Roberto Alomar to earn his second save of the season.
Rondell White, acquired this off-season from the Yankees, gave the Padres a 1-0 in the third when he hit a double -- right fielder Raul Gonzalez should have caught the ball but was undecided on whether or not to dive -- which drove in shortstop Ramon Vazquez.
The Mets (14-21) went ahead by a run in their half of the third after Roberto Alomar, who was hitting just .147 against left-handed pitching, hit his first homer of the year; a two-run shot off San Diego starter Mike Bynum.
San Diego (12-23) regained the lead in the top of the fifth when Rondell White, with runners on second and third, doubled to deep center that drove in both Ramon Vazquez and Mark Loretta. White came into the game with 10 HRs, 22 RBIs, and a .335 average against the Mets (56 games) in his career.
Jae Seo went five innings and allowed six hits, three runs, three walks, and fanned four. He left to pinch hitter Jason Phillips in the bottom of the fifth after throwing ninety-one pitches, fifty-one of them strikes.
Padres' starter Mike Bynum, in his first major league start against the Mets, pitched six solid innings surrendering just two hits, three runs, and two walks while striking out five.
Jason Middlebrook pitched the sixth and seventh and allowed just one hit... On Monday John Franco will begin a minor league rehabilitation assignment with Class A St. Lucie... David Cone, after throwing on the side on Thursday, hopes to begin a rehab assignment with St. Lucie some time this week... The Padres have one 8 of their last 10 games against the Mets at Shea Stadium... LHP Al Leiter (4-1, 3.38) faces San Diego in the middle game on Saturday afternoon...