Originally selected by the Padres in the 13th round of the 2000 First-Year Player draft, Germano made his Major League debut with San Diego on May 22, 2004 and became the 16th pitcher in franchise history to win his Big League debut. He compiled a 1-2 mark with an 8.86 ERA (21 ER/21.1 IP) in seven games for the Padres (five starts) during the 2004 season. Germano was traded along with right-handed pitcher Travis Chick to the Cincinnati Reds in exchange for third baseman Joe Randa on July 23, 2005.
Over parts of two Major League seasons with the Padres (2004) and Reds (2006), Germano is 1-3 with an 8.04 ERA (25 ER/28.0 IP) in nine career games (six starts) with 24 strikeouts and 17 walks. In 175 career minor league games (165 starts) over parts of seven seasons with the Padres (2000-2005), Reds (2005-2006) and Phillies (2006) organizations, Germano is 69-51 with a 3.69 ERA (421 ER/1026.2 IP).
The Padres 40-man roster now stands at 39, including 23 pitchers, two catchers, 10 infielders and four outfielders.