Madden was 0-2 with three saves and a 7.88 ERA for the Lake Elsinore Storm this season and has given up 15 hits in eight innings of work while striking out 10.
Right-hander Mike DeMark, who began the year in extended spring will take his place on the roster. It is unclear who will close in Madden's absence.
DeMark was having a good showing in extended after signing out of the independent leagues during the off-season.
In 2006, DeMark went 1-4 with a 3.22 ERA for the Florence Freedom of the Frontier League. In 64 innings he struck out 59 hitters and kept opposing batters to a .192 average.