Millwood recovered and seemed to be finding his way as the game entered the third inning with the Phillies trailing 1-0. Pat Burrell, who was dropped to seventh in the order, led off the third inning with a solo homerun as he battles to break out of a season long slump. Millwood and Padres' starter Clay Condrey battled back and forth in a 1-1 ballgame until the fifth inning.
After the Phillies failed in the top of the fifth, Ramon Vazquez homered with one out in the bottom of the inning and one out later, Ryan Klesko followed that with a solo homerun of his own, putting San Diego up 3-1 through five innings. Millwood worked out of the inning and completed the sixth before exiting after giving up eight hits and walking two through six innings. Millwood also struck out seven Padres on the night and was lifted for a pinch-hitter in the top of the seventh inning.
The bullpens battled things out through the regulation nine innings, but both faltered in the tenth. Mike Matthews (1-0) started the tenth inning for San Diego and promptly gave up a leadoff double to Placido Polanco, who had two hits in his first game action since coming off the disabled list. Bobby Abreu followed that with an RBI single, giving the Phillies a 4-3 lead with a runner on first. Matthews regrouped and got Mike Lieberthal to ground into a double-play and then struck out Jim Thome to end the inning.
Jose Mesa (1-2) came on to close things out in the tenth for the Phils, but failed miserably. Klesko led off the inning with a single and after Mesa struck out Rondell White, he walked Mark Kotsay and gave up a single to Nady to load the bases. Sean Burroughs then singled to rightfield, scoring Klesko and Kotsay with the tying and winning runs. It was the second blown save of the season for Mesa.
The Phillies and Padres play game two of the three-game series Saturday with Brett Myers (2-2, 2.20) going against Brian Lawrence (2-3, 3.86).