Burrell continued his career-long torment of the New York Mets, homering twice and driving in four runs, as the Phillies stormed back from a four-run deficit and posted an 11-7 victory.
Burrell's solo blast off Seo in the top of the sixth inning got the Phillies on the board, but they trailed, 4-1, heading to the seventh.
David Weathers replaced Seo to start the inning, struck out pinch hitter Nick Punto and retired Placido Polanco on a lineout around a single by Jimmy Rollins. Thome walked, but Weathers was one pitch from avoiding trouble when Burrell hit a 3-2 offering that just cleared the right field fence and tied it, 4-4.
Hitting just .213 heading into this three-game series, Burrell raised his career average against New York to .318 with 19 homers and 53 RBI.
"You can ask me all you want, I don't know," Burrell said of his success against the Mets. "I said it before. I don't know what it is. I just feel comfortable here. There's a good hitting background. You can see the ball really well here. You have to take advantage of that."
Graeme Lloyd (1-1) relieved Weathers but gave up a single to Bobby Abreu, the only batter he faced. After Pat Strange came out of the bullpen, Abreu stole second, Mike Lieberthal walked and David Bell put the Phillies in front with an RBI single. Ricky Ledee also walked and Punto produced another run with an infield hit. Rollins followed with a two-run single but was thrown out at second to end the inning.
The rally made a winner of starter Brett Myers (4-3), who gave up four runs and four hits in six innings with three walks and a strikeout.
Philadelphia padded its lead in the eighth on Thome's two-run homer and an RBI single by Ricky Ledee. It needed the cushion as New York scored three times in the ninth against reliever Carlos Silva.
Seeking their third straight win, the Mets struck quickly, taking a 2-0 lead in the bottom of the first on RBI singles by Roberto Alomar and Jason Phillips. They made it 4-0 in the third on a two-run homer by Cliff Floyd.
Seo deserved a better fate after yielding just one run and five hits in six innings with two walks and four strikeouts.