Wilkerson's third inning solo homerun gave Washington a 1-0 lead. Nick Johnson's RBI double in the sixth extended the lead to 2-0.
Brett Myers pitched well, going 6 2/3 innings, giving up two runs - one earned - on seven hits and one walk while striking out seven. He left in favor of Rheal Cormier, who came on to face Wilkerson in the seventh. Wilkerson tripled, but Cormier got Cristian Guzman to pop-up to end the inning without any damage.
Jim Thome put the Phillies on the board with an RBI single in the sixth and Pat Burrell followed with a monster homerun that went to the back part of the lower level in left field. Burrell's homerun gave the Phillies a 3-2 lead.
Tim Worrell (0-1) came on to pitch the eighth and quickly gave up a two-run homerun to Jose Guillen that put the Nationals back in front. Worrell gave up two more singles before exiting. Aaron Fultz gave up a single to Brian Schneider that Bobby Abreu misplayed in right field, allowing another run to score. Wilkerson's ground rule double completed the rally for Washington, giving them a 6-3 lead.
Terry Adams gave up another insurance run in the ninth.