The incident on Tuesday night, one in which a fan ran onto the field and grabbed umpire Laz Diaz only to get thrown to the ground and surrounded by security and Royals' players, happened on the final out of the eighth inning.
The first incident came last season when Royals first base coach Tom Gamboa was attacked by two fans. Security and Royals' players once again came to the defense.
Earlier in Tuesday nights game three fans ran onto the field, but did nothing else.
Wednesday's game was scheduled to start at 7:05 p.m. CT, with Jon Garland going up against Runelvys Hernandez.