Loaiza struck out eight Orioles in the game, giving him 27 on the season and 19 in his last two starts. Loaiza, who is now 4-0 in four starts, has a 1.24 ERA this season
Frank Thomas hit a first-inning home run off Orioles' starter Sidney Ponson to give the Sox an early 1-0 lead. Thomas went 2-4 in the game.
The only threat on Loaiza came in the third with two men on and two outs. BJ Surhoff reached on an infield single to second to D'Angelo Jimenez, who was slow to make the play, allowing Surhoff to beat the throw. Jeff Conine grounded out to end the inning.
Loaiza gave up just one more hit till the home run in the ninth, and allowed two baserunners, one coming through a Jose Valentin error at short.
The Sox added a second run in the fifth with a Joe Crede double, scoring Carlos Lee. Lee went 1-4, but didn't homer, breaking his five-game home run streak. Lee reached on a single and stole second base in the inning.
Loaiza was pulled after 101 pitches for Koch, who gave up two deep fly balls for outs, picking up his third save of the season.
Game two of the three-game set will be played on Wednesday at 6:05 p.m. CT, with Bartolo Colon going up against Jason Johnson.