Buehrle (2-3) picked up his second straight loss of the season, but he did right the ship after the first inning, holding the Twins to just two more hits and no runs.
Dustan Mohr started the first-inning rally with a double and scored on Corey Koskie's sacrifice fly with runners on the corner. Torri Hunter then hit an RBI triple and Michael Cuddyer had a RBI single.
After that Buehrle was masterful and kept the Twins grounded; a drastic improvement from his previous outing against Cleveland, where he gave up seven runs on 11 hits.
The umpires had to warn each team after Frank Thomas was hit in the fourth inning by Joe Mays. Buehrle hit Doug Mientkiewicz in the first inning, but insisted after the game it wasn't intentional. The Sox fans booed Mientkiewicz during each of his at bats. Each team hit two batters on the day. Magglio Ordonez was hit in the ninth inning by J.C. Romero. When the game was over Ordonez continued to stare at Romero. After the game Twins manager Rod Gardenhire said, "believe me, Romero wasn't throwing at him."
Newcomer Dave Sanders pitched 2/3 of an inning for the Sox giving up a two-run homer to Bobby Kielty. He gave up a total of three runs, two of which were earned. Ordonez and Jose Valentin each had a throwing error on the day.
Armando Rios got the start in left field with Aaron Rowand in center. Rowand's slump continued as he went 0-3. The Sox had a total of five hits on the night.
The Sox and Twins will play the second game of the series Saturday night at 6:05 CT. Jon Garland is expected to face Kyle Lohse.