The Sox added another run in the fourth with an Aaron Rowand single to left-center. Scoring was Carlos Lee, who reached first on a throwing error by third baseman Eric Chavez, and advanced to second on a high chopper to the pitcher by Joe Crede. Lee and Crede both went 0-4.
That was all the Sox managed to score off Zito and eventually Chad Bradford and Keith Foulke, who each threw a scoreless inning to end the game. Foulke, who was a part of the six-player deal between the Sox and A's in the off-season, picked up his seventh save.
As the Sox offense was silenced, the bats of Chris Singleton and fellow bottom-of-the-order hitter Eric Byrnes made noise. Byrnes singled and then scored off a Singleton triple in the fifth -- a Mark Ellis sacrifice fly scored Singleton to tie the game -- and later in the seventh Byrnes doubled before Singleton's single drove him in, putting the A's up 3-2.
Colon left after eight innings and 115 pitching, giving up three runs off six hits and two walks. Colon struck out five in the game. Kelly Wunsch threw a scoreless ninth inning in relief.
Jose Valentin led off with a pinch-hit double in the eighth, but a Frank Thomas lineout to third, Magglio Ordonez groundout back to Foulke, and Lee lineout to first ended the inning. The Sox went down 1-2-3 in the ninth.