Offensively the Sox were once again shutdown, this time by right-hander Ryan Franklin, who gave up two runs (1 earned) in eight innings. D'Angelo Jimenez went 3-4 with a run scored. The Sox had only five hits and grounded into four double plays.
Loaiza started the first inning with two quick outs, but two straight singles, two walks and another singled scored two runs. The inning ended when Carlos Lee threw John Olerud out at home plate on the single.
The Sox scored with the help of the Mariners defense in their half of the first. After Jimenez led off with a single, Willie Harris hit a soft grounder to second that was bobbled by Brett Boone. With two men on, Frank Thomas walked to load the bases for Magglio Ordonez, who grounded into a double play, scoring Jimenez.
Harris, who was just called up on Thursday in place of Aaron Rowand, went 0-4 with a RBI and throwing error in center. The 2-9 hitters on the Sox went a combined 2-25.
The Mariners added another three runs in the fourth off Loaiza before he was replaced by Glover. Glover ended the inning, but gave up three more runs before leaving in the seventh. Lefty Dave Sanders finished the game for the Sox, throwing 2 2/3 scoreless innings.
The Sox scored their second run with a Harris groundout in the sixth, scoring Miguel Olivo. Olivo went 1-3 in the game. Paul Konerko went 1-4.
The Sox will play game two of the three-game set on Saturday night at 6:05 CT, with Josh Stewart going up against Freddy Garcia. The game will televised on WGN.