Things were no different for the Sox. Esteban Loaiza threw another impressive game, giving up just one run in seven innings, but it was one run too much as the bats were shutdown by Detroit starter Gary Knotts and reliever Franklyn German. Knotts threw 7 2/3 innings, striking out six.
The only run of the game came in third inning off a RBI-sacrifice fly by Omar Infante, scoring Brandon Inge, who tripled.
The triple was the first of five hits off Loaiza, who walked four and struck out five on 97 pitches. Despite his second loss of the season, Loaiza lowered his ERA to a major league leading 1.92. Second is Walt Williams with a 2.25 ERA. Loaiza is tied for the lead in wins with seven.
The Sox had two men on with two outs in the eighth, but Jose Valentin, 0-4, was out on strikes.
Along with the loss came a mini-scare when Carlos Lee was hit on the head with a pitch -- a breaking ball -- from Knotts in the seventh inning. Lee was on the ground for a few minutes before he walked off the field. There has been no word yet on his status.
The Sox play the final game of the series on Sunday at 1:05 p.m. CT with the hopes of preventing a series sweep. Danny Wright is scheduled to pitch against righty Adam Bernero. The game will be televised on Fox Sports Net Chicago.