With Bartolo Colon and Carlos Zambrano on the mound for the Sox and Cubs respectively, few expected a high-scoring game, which looked to be in motion after a three-run first by both teams.
The Cubs scored with the help of control problems by Colon, who walked three in the inning and seven for the game. The runs came across on a bases-loaded walk by Eric Karros and two-run single by Troy O'Leary.
The White Sox scored all their runs in the first and third innings with two outs and nobody on.
With two outs in the first, Frank Thomas doubled and Magglio Ordonez walked, setting up Carlos Lee and Jose Valentin for back-to-back doubles, tying the game at 3-3.
The Sox took the lead in the third with a Lee two-out, RBI-single, which was hit down the line and off the leg of first-base umpire Alfonso Marquez. Karros recovered the ball, but was unable to make the throw to home in time, allowing Lee to reach second.
The hustle of Ordonez, who extended what looked to be a single into a double, turned up big as after an intentional walk to Valentin, Paul Konerko hit a soft liner for the final out.
Valentin was intentionally walked to bring up Konerko twice in the game. Both times paid off for the Cubs as Konerko went 0-3, stranding six baserunners.
Colon battled the rest of the way, but couldn't overcome his control as two walks in the fifth set-up a two-run single by Karros, putting the Cubs up 5-4. Two more back-to-back walks in the sixth with one out ended Colon's night as Dave Sanders came in to pitch, giving up a RBI-single to Corey Patterson.
The Sox' ninth started with a walk to Ordonez, who advanced to second after a 12-pitch at bat between Lee and reliever Juan Cruz ended in a fly out to deep right.
With lefty Mark Remlinger replacing Cruz, Valentin was turned around and struck out for the second out. Tony Graffanino, who pinch-hit for Brian Daubach right after he pinch-hit for Konerko, was intentionally walked to bring up Jimenez and his game-winning single.
The game, which took just under three and a half hours to play, would've ended after the Cubs' half of the ninth if it weren't for the great defense showcased by Cubs' outfielders Sammy Sosa and Troy O'leary in the seventh.
With Ordonez and Thomas on first and second respectively, both Lee and Valentin hit deep shots; one that was caught over the shoulder of O'Leary in left and the other on an over-the-wall grab by Sosa, robbing Valentin of a homer.
The White Sox had eight hits in the game, five coming from Ordonez (2) and Lee (3), who are 8-16 with four RBIs and five runs scored in this series. Konerko, Joe Crede and Miguel Olivo each went 0-3, while Harris, Rowand and Thomas had a hit each.
The Sox will once again attempt to sweep the Cubs on Sunday, with Esteban Loaiza going up against Kerry Wood. Gametime is at 1:05 p.m. CT and will be televised on Fox Sports Net Chicago.