The Pacers (15-24) turned to West, who scored a game- and season-high 28 points, in the final two minutes of a dramatic conclusion. He scored twice to give the visitors a one-point lead. Center Roy Hibbert also scored as the lead kept changing hands.
But the 76ers (7-29) had the final basket as Michael Carter-Williams scored on a finger-roll layup with 9.9 seconds remaining. West got the ball for the final shot, backed his defender in and then pulled back for a 15-footer that fell short.
The loss was obviously disappointing for the Pacers, who had won four of six before facing a team with one of the NBA’s worst records.
Tony Wroten led the 76ers with 20 points off the bench. Rodney Covington scored 15 and Carter-Williams 15.
Indiana lost despite a 12-point advantage at the free-throw line. But the Pacers could have made more of their foul shots. They hit 30-of-42 to the 76ers’ 18-of-25.
West sank 10-of-18 field-goal attempts as well as 8-of-10 foul shots to go with nine rebounds.
Pacers reserve forward C.J. Miles was lost late in the first quarter when he suffered a left eye injury. Miles has been the Paces’ best bench scorer this season, but had only one 3-pointer in this game.
The 76ers had a 46-22 advantage in bench scoring.
The Pacers return home to Bankers Life Fieldhouse next week to host the Minnesota Timberwolves (5-30) on Tuesday and the Detroit Pistons (12-24) on Friday before hitting the road again for Saturday visit to Charlotte (14-24).
Phillip B. Wilson can be found on Twitter (@pwilson24), Facebook and Google+.