Last week, Vick suffered a concussion in the Eagles' 35-31 loss to the Atlanta Falcons, but made a quick recovery and started Sunday's 29-16 loss to the New York Giants.
But Vick appeared to fracture his non-throwing hand late in the third quarter Sunday. He stayed in the game for a few plays after the injury, and even ran an unsuccessful quarterback sneak from the 1-yard line.
But after X-rays initially indicated that the hand was broken, Vick was removed from the game. He had a CT scan on the hand Monday morning that revealed a much more promising prognosis in Vick's hopes to return to the field against the 49ers.
During his day-after news conference Monday, Eagles coach Andy Reid alleviated concerns about Vick, telling reporters that Vick has a contusion in his right hand that will only be a day-to-day injury. Vick's CT scan revealed the lesser extent of the injury.
He could play against the 49ers if the swelling in his right hand subsides to a manageable degree this week. Earlier reports Sunday suggested Vick could miss several games.
"It's not to say that he can't play with the swelling," Reid said. "It's just got to be where he can bend his hand and work with it. It's a day to day thing as opposed to what we initially thought it was. The MRI came back and it wasn't a negative thing there."
Vick's hand swelled up considerably after the injury, and Vick was under the impression his hand was indeed broken after the game.
"I don't know," Vick said late Sunday when asked whether he thought he would be able to play. "I don't know if I'm going to be able to play or not. I don't know anything right now, except my hand is broken and we have to figure out what is the next move."
"It's tough, you know," said Vick, who completed 16 of 23 passes Sunday, but had a first-quarter interception in the red zone when a pass for Steve Smith clanged off the wide receiver's hands.
"Everything is not going to be fine and dandy, and we understand that. This is the National Football League. Just because we're in this situation right now (a 1-2 start), things could change drastically over the next couple of weeks and I think they will. I believe it. And just a couple of bad breaks and things are not going our way right now. But it's up to us to get it turned around."
It's going to be a lot tougher turning it around if they're without Vick for a while. After he left the Atlanta game with a concussion, second-year man Mike Kafka replaced him and played pretty well, completing seven of nine passes and almost leading the Eagles to a come-from-behind win.
Sunday, though, things didn't go so well. Kafka threw a pair of interceptions, including one that set up a Giants score in the 13-point loss to a divisional rival that also made the playoffs last season.
There also is a possibility Reid could turn to Vince Young. Young missed the first two games with a hamstring strain. He was activated for the Giants game, but Kafka got the call when Vick got hurt.
"I went with Kafka," Reid said when asked if he considered using Young Sunday.
The Eagles always have been a passing team, but LeSean McCoy is off to one of the best starts in history by an Eagles running back.
He notched his second 100-yard game of the season Sunday against the Giants and has rushed for 345 yards in the Eagles' first three games. Much of his rushing yardage has come out of one-back, two-tight end sets. The Eagles' 40 rushing attempts Sunday were their most since December of 2008.
McCoy and Philly's rushing game could be the stiffest test yet for a San Francisco rushing defense that has established itself as one of the NFL's best this season. The 49ers rank third in the league, allowing just 62.7 yards rushing per game, and have gone 25 consecutive games without allowing a 100-yard rusher, by far the longest streak in the NFL.
Safety Kurt Coleman was benched in the first half Sunday after two missed tackles on the same play. He twice failed to bring down Giants wide receiver Victor Cruz on his 74-yard touchdown catch and run.
Coleman, a 2010 seventh-round pick, was replaced by Nate Allen. It remains to be seen who will start next week against the 49ers – Allen or Coleman.
Wide receivers Jeremy Maclin and Riley Cooper also were injured against the Giants and their status this week is uncertain.
Maclin suffered a hamstring injury and could be sidelined for this week's game. Cooper suffered a concussion blocking on a kickoff return. The severity of the concussion still isn't known.
Cornerback Brandon Hughes, one of the Eagles' better special teams players, suffered a hamstring strain against the Giants that could keep him out against the 49ers.