--- The 49ers won for the 42nd time in team history on the Monday Night Football stage, second in the NFL to the Dallas Cowboys, who have 43 MNF victories. The 49ers improved to 42-25 on Monday Night Football, including 19-14 on the road.
--- The Niners improved their prime time record to 63-32 overall and to 25-17 on the road.
--- San Francisco improved to 5-1 against the Cardinals on Monday Night Football, including going 4-1 against Arizona on MNF since 2007.
--- Coupled with last week's 13-6 win vs. Seattle on Thursday Night Football, the 49ers have won back-to-back prime time games for the first time since October of 2001, when San Francisco beat the Jets 19-17 in New York and the Carolina Panthers 24-14 in San Francisco.
--- The Niners improved to 7-1 in NFC West divisional games under head coach Jim Harbaugh and 2-0 against the NFC West this season. The seven divisional wins are tied for the second-most most in the NFL since 2011.
--- The victory avenged San Francisco's only divisional defeat during that span, a 21-19 loss to the Cardinals here at University of Phoenix Stadium last December.
--- San Francisco improved its overall record against the Arizona Cardinals to 25-17, and 11-9 on the road.
--- The 49ers have won at least six of their first eight games for the second consecutive season (7-1 in 2011), the first time the team has done so in back-to-back seasons since 2001-02.
--- The 49ers improved to 12-3 under Harbaugh when scoring first.
--- The 49ers have gone 16-4 against the NFC West since 2009. The 16 wins are tied for the most divisional wins in the NFL during that span. The New England Patriots also have gone 16-4 over that span in the AFC East.
--- Quarterback Alex Smith completed 18 of 19 attempts for 232 yards, three touchdowns and a quarterback rating of 157.1. Smith set the single-game NFL record with a 94.7 comp. pct. with a minimum of 15 attempts, breaking the record previously held by Denver's Craig Morton and Minnesota's Fran Tarkenton, who each completed 17 of 18 passes in a game for a completion percentage of 94.4.
--- Smith set a career high with a 93.3 completion percentage (14 of 15) in the first half. His previous career high was a 91.7 (11 of 12) completion percentage against Arizona during his rookie season of 2005.
--- Smith tied his career high with three touchdown passes. This marks the eighth career 3 TD performance for Smith, with the last coming vs. Buffalo on Oct. 7.
--- Smith is 19-5 as a starter since the beginning of the 2011 season. The 19 wins are tied for the most in the NFL during that span with Green Bay's Aaron Rodgers.
--- Wide receiver Michael Crabtree registered the second two-touchdown performance of his career, hauling in a team-high five receptions for 72 yards. He also had a two-touchdown game in the 2011 season finale at St. Louis.
--- Crabtree has now played in 50 regular-season games and has registered at least one reception in every game of his career.
--- Wide receiver Randy Moss recorded a 47-yard touchdown reception, marking his second TD of the season and 155th of his career.
--- Moss has now registered 18 TDs in 19 games on Monday Night Football. His latest touchdown ties Moss with Terrell Owens in fourth place among the NFL's all-time leaders with 156 TDs.
--- The 49ers improved to 18-0 under Harbaugh when running backs Frank Gore and Kendall Hunter combine for 20 carries or more. Gore led the way with 55 yds. rushing on 16 carries, while Hunter added 43 yds. on 10 carries.
--- The San Francisco defense held Arizona to just seven yards rushing, tying the fewest rushing yards the 49ers have allowed in a single game in franchise history. The Niners also allowed just seven yards on the ground during a 37-2 victory at New Orleans in 1972.
--- The seven rushing yards allowed is the lowest output allowed in the NFL this season, surpassing the Tampa Bay Buccaneers, who held Carolina to 10 rushing yards in September.
--- The 49ers defense did not allow a TD for the 4th time this season. This is the 6th time in franchise history that San Francisco has held its opponents out of the end zone in 4 games in a single season (2011 (4), 2009 (5), 2001 (4), 1984 (4), 1971 (4).
--- The 49ers have given up just 9 touchdowns this season, tied for the fewest in the NFL with the Chicago Bears, who have played one fewer games.
--- With two sacks on the day, outside linebacker Aldon Smith now has 21.5 career sacks. Smith reached 20 career sacks in just 24 games, becoming the second-fastest in 49ers history, behind Hall of Famer Fred Dean who reached 20 sacks in 23 games from 1982-83.
--- Smith brought down Arizona quarterback John Skelton twice in the fourth quarter, giving him a team-leading 7.5 sacks on the season.
--- Ahmad Brooks, San Francisco's starting outside linebacker opposite Smith, tallied his fourth sack of the season and 24th of his career, taking down Skelton in the fourth quarter.
--- Middle linebacker NaVorro Bowman sacked Skelton late in the second quarter on a blitz, giving Bowman two sacks for the season and four for his career. Bowman's two sacks on the season ties his career-high (two in 2011).
--- Chris Culliver notched his second interception of the season and third of his career, picking off Skelton as the first half ended.
--- Cornerbacks Culliber and Tarell Brown each registered five passes defensed, setting a new career high for both of them. According to the NFL Gamebook statistics, the 5 PDs by Brown and Culliver are tied for the most in the NFL this season, along with Denver cornerback Tracy Porter, who had five in a September game against Pittsburgh.
--- With his 43-yard field goal against the Cardinals, kicker David Akers has now made at least one field goal in each of his 24 games as a 49er, extending his franchise record for most consecutive games with a field goal.
--- Tight end/long-snapper Brian Jennings has now played in 200 consecutive games, the second-longest streak in 49ers history to offensive tackle Len Rohde, who played in 208 consecutive games as a 49er.
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