Nose tackle Ian Williams, who required four surgeries to repair a broken ankle suffered last season, may have hit another significant bump in the road.
"Ian, we’ll see. It looks like he may have a little bit of a small fracture," 49ers coach Jim Harbaugh said after Sunday's 27-24 overtime win in New Orleans.
Williams left Sunday's win over the Saints in the second quarter with an apparent left leg injury and did not return.
Without another nose tackle on the roster, allowed 136 rushing yards to the Saints, relying on second-year defensive lineman Quinton Dial to play in Williams' place.
Harbaugh wouldn't elaborate on the extent of Williams' potential fracture, but given his history with that left leg and the position he plays, his availability for the remainder of the season is very much in doubt.
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Glenn Dorsey will be entering the third week of his practice window while the 49ers gear up for next week's trip to play the New York Giants. There is a good chance Dorsey is elevated from injured reserve after being given the return designation following his torn biceps tendon sustained early in training camp with Williams out.
"We’ll see," Harbaugh said. "This past week, he had a good week of practice and we’ll go again this week and see if he can build on that and see where he’s at as the week goes on."
The 49ers also lost punt and kick returner Bruce Ellington in second quarter with a leg injury. He status is unknown. Fellow rookie Carlos Hyde took over kick return duties while corner Perrish Cox handled punts.