Kyle Terada-USA TODAY Sports

49ers running back Reggie Bush will not travel to play Sunday in Arizona

49ers running back Reggie Bush will miss his second straight game with a strained left calf.

SANTA CLARA, Calif. - Running back Reggie Bush has been ruled out of Sunday's game against the Arizona Cardinals, the 49ers announced Saturday, marking the second straight game Bush has missed with a strained left calf. Initially, Bush was listed as doubtful to play in the team's first divisional game.

Bush hasn't returned to practice since suffering the injury in the first quarter of Week 1's win over the Minnesota Vikings, and spent Friday's practice doing conditioning drills on the side field. He'll stay in Santa Clara over the weekend to continue rehabbing the injury.

"What I don’t want to do there is we could probably do one of those 80-percenter things and I’m not interested in 80 percent," head coach Jim Tomsula said. "To me, 80 percent starts to linger. If he’s really rolling and feeling really good then we will move accordingly, but if there’s anything there, we’re not going to do it."

Bush's agility drills Friday included bouncing and jumping off his left leg. He showed no ill effects, although he appeared hindered in his running.

Tight end Vance McDonald (knee) and receiver/return specialist Bruce Ellington (ankle) are listed as questionable. Both players practiced this week and appear likely to play.

Bush being sidelined means Carlos Hyde's backups will be Mike Davis and Jarryd Hayne. Those players combined for 17 yards on nine carries (1.89-yard average) in last week's loss to the Steelers, when Hyde left the game in the second half to get evaluated for a concussion, which he tested negative.

A day after the game, Tomsula announced Hyde sustained a contusion in his leg, which stemmed from a hit in the first half from Steelers safety Mike Mitchell. Hyde appeared to be wrapped up on the play, before Mitchell hit Hyde close to his knee. Despite its appearance, Hyde did not believe Mitchell's hit was dirty.

"He just tried to hit me low," Hyde said Friday. "Not too many guys are trying to hit me high. So, got to be ready for it. I know that."

For the Cardinals, receiver J.J. Nelson (shoulder) will not play. Running back Andre Ellington, who suffered a knee injury in the season opening win over New Orleans, is doubtful to play.

Former 49ers guard Mike Iupati is listed as questionable with a knee injury. He hasn't played yet this season, making it a possibility his debut with the Cardinals will come against his old team.

San Francisco drafted Iupati with the 17th-overall pick in the 2010, six picks after landing right tackle Anthony Davis, 25, who suddenly retired in June. Iupati signed a five-year, $40 million deal in the spring to join the Cardinals.

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Chris Biderman is the Editor-in-Chief of Niners Digest and covers the 49ers from their headquarters in Santa Clara. Chris has been writing about the team since the spring of 2013. The Ohio State alum received his Journalism degree in 2011 and has been working in sports media since 2008. Chris, a Santa Rosa, Calif. native, is also a contributor to the Associated Press covering sports throughout the Bay Area. You can follow Chris on Twitter here.

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