Charles LeClaire-USA TODAY Sports

49ers tight end Vernon Davis missed practice Wednesday with a knee injury

One of the 49ers' most targeted pass catchers did not practice Wednesday.

SANTA CLARA, Calif. - San Francisco 49ers tight end Vernon Davis did not practice with the team Wednesday in preparation with for the Green Bay Packers. Davis left Sunday's 47-7 loss in Arizona with a knee injury and did not return.

"We're going to see how he's doing here," head coach Jim Tomsula prior to Wednesday's practice.

Davis was targeted twice in Sunday's loss, with both passes from Colin Kaepernick intercepted by Cardinals defenders. The first came on the team's opening possession, when Justin Bethel returned it 21 yards for the game's opening touchdown. Tyrann Mathieu had the other coming just before half time.

Davis' status for Sunday's game against the Packers is unknown. He's been targeted the second most of any 49ers pass catcher (15), coming in behind receiver Anquan Boldin. Davis has eight catches for 109 yards on the season.

Running back Reggie Bush returned to the practice field for the first time since sustaining a calf injury in the opener against the Vikings. Bush had to leave the game after receiving just two carries and did not travel with the 49ers to either Pittsburgh or Arizona over the last two weeks to continue treatment.

Bush's presence Sunday, if he plays, could give Kaepernick a much-needed target on check downs to help avoid pressure from Green Bay's defense.

"Reggie’s a play maker," receiver Torrey Smith. "So we’re looking forward to having him back and I definitely think it’s going to take some pressure off Kap. If you feel like you can check the ball down or something, Reggie can go 40 or 50 yards downfield. That’s something that we can use."

Kaepernick is the league's most oft-pressured quarterback, getting put under duress on 43 percent of his drop backs, according to Pro Football Focus. The 49ers yielded eight sacks through three weeks, tied for the fourth most in the league, behind a new-look offensive line.

The center and right guard positions, held by Marcus Martin and Jordan Devey, have been under scrutiny in the early going. But Tomsula said he doesn't plan on making any changes in the starting lineup.

"My first reaction when something's not going right is to throw somebody out and put somebody else in," Tomsula said. "That's not the way I think."

Inside linebacker NaVorro Bowman did not practice Wednesday, and isn't expected to practice Wednesdays as the season goes on, while the training staff continues to monitor his surgically-repaired left knee. Bowman said he tweaked his knee in the second half in Arizona, but it didn't prevent him from continuing to play.

For now, the 49ers will play it safe with the three-time All-Pro, like they did each Wednesday with former defensive lineman Justin Smith. His days off became known as "Cowboy Wednesday."

Additionally, receiver and return specialist Bruce Ellington was back on the practice field Wednesday after missing the last two games with an ankle injury. So was tight end Vance McDonald, who missed the loss in Arizona with a leg contusion he suffered against the Steelers.

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Chris Biderman is the Editor-in-Chief of Niners Digest and covers the 49ers from their headquarters in Santa Clara. Chris has been writing about the team since the spring of 2013. The Ohio State alum received his Journalism degree in 2011 and has been working in sports media since 2008. Chris, a Santa Rosa, Calif. native, is also a contributor to the Associated Press covering sports throughout the Bay Area. You can follow Chris on Twitter here.

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